منابع مشابه
A Simulator for Evaluating Methods for the Detection of Lesion-Deficit Associations Short Title: Evaluation of Lesion-Deficit Analysis
Although much has been learned about the functional organization of the human brain through lesion-deficit analysis, the variety of statistical and image-processing methods developed for this purpose precludes a closed-form analysis of the statistical power of these systems. Therefore, we developed a lesion-deficit simulator (LDS), which generates artificial subjects, each of which consists of ...
متن کاملThe first step in modern lesion-deficit analysis
Sir, I am grateful to Karnath and his colleague (Karnath and Smith, 2014) for a sophisticated commentary on our recent study (Mah et al., 2014); nonetheless, four aspects of their analysis may cause some readers to misapprehend our conclusions in a way that will tend to perpetuate the errors it was our original aim to correct. First, the principal reason for changing to multivariate inference i...
متن کاملWhat affects detectability of lesion–deficit relationships in lesion studies?
Elucidating the brain basis for psychological processes and behavior is a fundamental aim of cognitive neuroscience. The lesion method, using voxel-based statistical analysis, is an important approach to this goal, identifying neural structures that are necessary for the support of specific mental operations, and complementing the strengths of functional imaging techniques. Lesion coverage in a...
متن کاملHuman brain lesion-deficit inference remapped
Our knowledge of the anatomical organization of the human brain in health and disease draws heavily on the study of patients with focal brain lesions. Historically the first method of mapping brain function, it is still potentially the most powerful, establishing the necessity of any putative neural substrate for a given function or deficit. Great inferential power, however, carries a crucial v...
متن کاملThe dimensionalities of lesion-deficit mapping
Lesion-deficit mapping remains the most powerful method for localising function in the human brain. As the highest court of appeal where competing theories of cerebral function conflict, it ought to be held to the most stringent inferential standards. Though at first sight elegantly transferable, the mass-univariate statistical framework popularized by functional imaging is demonstrably ill-sui...
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ژورنال
عنوان ژورنال: NeuroImage
سال: 2008
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2008.01.014